GPAT-2022 Paper Analysis-Pharmacology
EXAM PATTERN
|
Type of Questions
No.
of Questions Maximum Marks |
|
Pharmaceutical
Chemistry & Allied Subjects 38
152 |
|
Pharmaceutics &
Allied Subjects
38
152 |
|
Pharmacognosy &
Allied Subjects
10
40 |
|
Pharmacology &
Allied Subjects 28
112 |
|
Other
Subjects
11
44 |
|
Total
125
500 |
Topics covered in Previous Year -Pharmacology
GPAT-2022 Questions With Answers
1- 1- Match List I with List II Match the following with their mechanism of
action
|
List I
List II |
|
Mechanism of
action
Drugs |
|
A. DPP4 inhibitors
I. Metformin |
|
B. KATP Channel
blocker
II. Pioglitazone |
|
C. PPARγ activator III. Glimepiride |
|
D. AMPK Activator IV. Teneligliptin |
|
V. α glucosidase
inhibitors |
Choose the correct answer from the options given
below:
- 1.
A -II, B -V, C -III , D -IV ,
- 2.
A - II, B - III, C -IV, D -I
- 3. A -IV, B -III, C -II, D -I
- 4.
A -IV, B - I, C -V, D -III
Pharmacology – Anti-Diabetic
2- 2- Match the following phases of clinical trial with their significance
|
List I
List II |
|
A. Phase I P.
Post marketing surveillance |
|
B. Phase_0
Q. Micro dosing |
|
C. Phase_3
R. First in human dose |
|
D. Phase_4
S. Multicentric trials |
Choose the correct answer from the options given
below:
3-
A-R, B-Q, C-P, D-S
4-
A-R, B-Q, C-S, D-P
5-
A-Q, B-S, C-P, D-R
6-
A-S, B-P, C-Q, D-R
General Pharmacology
3- Which of the following statement/s are correct
regarding the alkylating agents as anticancer
agents:
A. They get converted into highly nucleophilic
anions and bind to the nitrogen atom of guanine
intercalating the DNA strands
B. Cyclophosphamide and busulfan belong to this
class
C. They inhibit the DNA synthesis by inhibiting
the DNA polymerase enzyme
D. They inhibit the DNA supercoiling by
irreversibly inhibiting the DNA topoisomerase enzyme
Choose the correct answer from the options given
below:
- 1-
A, B and D only are correct
- 2-
Only B is correct
- 3-
Only A and B are correct
- 4- A, B, C and are correct
Pharmacology- Anti- Cancer
4- Match
List I with List II Match the following drugs with their classes.
|
List I List
II |
|
Drugs
Classes |
|
A. Anakinra
I. IL-2 receptor antagonist |
|
B. Basiliximab II.
TNFα inhibitors |
|
C. Infliximab
III. Calcineurin inhibitors |
|
D.Tacrolimus
IV. mTOR
inhibitors |
|
V. IL-1 receptor antagonist |
Choose the correct answer from the options given
below:
- 1-
A -III , B -II , C -I , D - IV
- 2-
A -V, B -II , C -III, D - I
- 3-
A -I , B -III , C -V , D -II
- 4- A -V , B -I , C -II , D - III
Pharmacology- Anti-Rheumatoid Drugs
5-Which of the following is a malignant type
of tumor?
- 1-
Lipoma
- 2-
Adenoma
- 3- Melanoma
- 4-
Osteoma
Pharmacology – Anti-Cancer Drugs
6-In human body ----- system operates to
maintain pH of blood plasma.
- 1-
The acetate buffers
- 2-
The lysis buffers
- 3-
The potassium citrates
- 4- The carbonic acid
HAP- The blood
6-Blood grouping is basically possible because
of the presence of following:
- 1- Antigens on RBCs
- 2-
MHCs on WBCs
- 3-
MHCs on RBCs
- 4-
Antigens on WBCs
HAP - The blood
7-The objective of the Abbreviated New Drug
Application is to …
- 1-
get approval to conduct clinical trials
- 2-
get market approval of new chemical entities
- 3- get market approval of generics
- 4-
get approval for animal studies of new chemical entities
General Pharmacology
8- Which of the following could be the
reason(s) for Pharmacokinetic Drug Interactions?
A. Interference with absorption
B. Changes in protein binding
C. Competition at receptor sites
D. Interference with renal excretion
Choose the correct answer from the options
given below:
- 1-
A, B and C only
- 2- A, B and D only
- 3-
A, C and D only
- 4-
C only
General Pharmacology
9- Formation and maintenance of myelin sheath
around CNS axons are done by
- 1- Schwann cells
- 2-
Oligodendrocytes
- 3-
Microglia
- 4-
Astrocytes
HAP - CNS
10- Which of the following statement is true
for the periosteum of bone
- 1-
Protects the bone by assisting in fracture repair
- 2-
Has osteogenic cells which enable bone to grow in thickness, but not in
length
- 3 It is composed of an outer fibrous layer of dense irregular connective tissue and an inner osteogenic layer that consists of cells
- 4-
All of these
HAP- Skeletal system
11- Which of the following clinical feature is
not responsible for insulin resistance in type 2 diabetes?
1- Increased LDL
2- Increased HDL
3- Reduced HDL
4- Increased triglycerides
Pharmacology- Anti-Diabetic Drugs
12- Which of the following is a specific enzyme
marker of cell death in acute myocardial infarction?
1- Creatine Kinase-MB
2- Aspartate aminotransferase
3- Lactate dehydrogenase
4-
Cardiac troponin
Pathophysiology
13- Nitric oxide synthase exists in __________
1- Two isoforms
2- Three isoforms
3- Four isoforms
4- Five isoforms
Pharmacology – Angina
14- Viable cells (viability assay) are assayed by
all of the following methods except
1- MTT/MTS/Resazurin assay
2- Apoptosis assay
3- ATP assay
4- Protease marker assay
Pathophysiology
15- Which of the following statements are true
with the Adverse Drug Reactions?
A. Any response to a drug which is noxious and
unintended.
B. Which occurs at doses normally used in man for
prophylaxis, diagnosis or therapy of a disease.
C. Adverse drug event is same as that of Adverse
Drug Reaction.
D. Which occurs at normal dose or overdose when
used for prophylaxis, diagnosis or therapy of a
disease.
Choose the correct answer from the options given
below:
1- A and B are true while C and
D are false
2- A and C are true while B and
D are false
3- B, C and D are false, Only A
is true
4- A, B and C are false, Only D
is true
General Pharmacology
16- Which of the statement is true in geriatrics
practice?
1- The incidence of Adverse Drug
Reactions diminishes with advancement of age.
2- Dose reduction is inevitable
for each and every drug used in geriatric patients. ,
3- Patient compliance is
highest in geriatric patients
4-
Polypharmacy is often a problem in elderly.
Clinical Pharmacy and therapeutics- drug
interaction in pediatric and geriatric patients
17- The ‘Up-and-Down’ method for a projected LD50
determination is described in the
1- OECD Guideline 401
2- OECD Guideline 420
3- OECD Guideline 423
4-
OECD Guideline 425
General Pharmacology
18- Match List I with List II
|
List I
List II |
|
(Poisoning)
(Treatment) |
|
1. Warfarin P.
Pralidoxime |
|
2. Carbon monoxide Q. Oxygen |
|
3. Cyanide R. Vitamin K |
|
4. Nitrites S. Dicobalt edetate |
|
5. Organophosphates
T. Methylene blue |
Choose the correct answer from the options given
below:
1- 1: R, 2: Q, 3: S, 4: T, 5: P
2- 1:P, 2: Q, 3: T, 4: S, 5:
R
3- 1: Q, 2:S, 3:P, 4: R, 5: T
4- 1: T, 2: Q, 3: R, 4:P, 5:S
General Pharmacology
19- Which of the following is/are not true about
Parkinson’s disease?
A. Parkinson’s disease is caused by the degeneration
of the substantia nigra in the midbrain.
B. Parkinson's disease is caused by the
degenerative loss of nigrostriatal dopaminergic neurons.
C. Bradykinesia, rigidity and tremor are the main
symptoms in Parkinson’s disease.
D. Parkinson's disease is caused by the
degenerative loss of nigrostriatal cholinergic neurons.
Choose the correct answer from the options given
below:
1- A, B and D only
2- A, B and D only
3- C only
4-
D only
Pharmacology- Drug Acting on PNS
20- Tendon rupture or tendonitis of Achilles
tendon is an adverse reaction of
1- Fluoroquinolones
2- Tetracyclines
3- Cephalosporins
4- Aminoglycosides
Pharmacology- Antibiotics Drugs
21- Regarding Bromocriptine, which of the
following statement is TRUE It is a relatively selective dopamine D2 agonist
with prominent action
A. on pituitary lactotrophs (inhibit prolactin
release)
B. in striatum (antiparkinsonian)
C. in CTZ (antiemetic)
D. as an adjunctive treatment for type 2 DM
Choose the correct answer from the options given
below:
1- A, B and D only
2- A, B and C only
3- B and D only
4- A and B only
Pharmacology- Drug Acting on PNS
22- Reason for the combination of Diphenoxylate
(2.5 mg) + Atropine (0.025 mg) is to
1- Inhibits the side effects of
Diphenoxylate
2- Discourage abuse of
Diphenoxylate
3- Augment the anti-motility
action of Diphenoxylate
4- Suppress
gastroenteritis-related vomiting
Pharmacology
23- Which of the following type is a reversible
cell injury?
1- Karyolysis
2- Nuclear clumping
3- Phagocytosis
4- Cytoskeletal damage
Pathophysiology
24- A neonate suffering from icterus is
intravenously administered with phenobarbital. The
justification for this therapy is:
1- Phenobarbital is a short
acting barbiturate and hence safe to induce sleep in neonates
2- Phenobarbital suppresses the bilirubin
synthesis in neonates
3- Phenobarbital suppresses
hepatic glucuronyl transferase and increases clearance of bilirubin,
4- Phenobarbital induces
hepatic glucuronyl transferase and increases clearance of bilirubin,
General Pharmacology
25- The quadruple therapy of Helicobacter pylori
infection includes
1- Bismuth subsalicylate,
metronidazole, tetracycline and a proton pump inhibitor
2- Streptomycin, metronidazole,
tetracycline and a proton pump inhibitor
3- Sulfasalazine, metronidazole,
tetracycline and a proton pump inhibitor
4- Bismuth subsalicylate,
metronidazole, azithromycin and a proton pump inhibitor
Pharmacology- Antibiotics
26- When RBCs are kept in isotonic NaCl solution
1- There will not be any
movement of solutes across the RBC membrane
2- The RBC shape and size will
not change
3- Because the osmotic pressure
across the membrane is same the solutes will not cross across the RBC membrane
4- All of these
General Pharmacology
27- Which statements are not true about the
grafts?
A. Isografts are grafts in which the donor and
recipient is the same individual.
B. Autografts are grafts between the donor and
recipient of the same genotype.
C. Allografts are those in which the donor is of
the same species but of a different genotype
D. Xenografts are those in which the donor is of
a different species from that of the recipient.
Choose the correct answer from the options given
below:
1- A, B and D only
2- A and B
3- B and C
4- C and D
HAP
28- At the site of tissue injury, the activated
platelet releases ADP and activates surrounding platelets to form
platelet-plug, but this process will not continue to activate whole platelets
in the body to form a massive ball of platelets because
1- The adjacent normal
endothelial cells physiologically release ‘NO’ which is a platelet inhibitor
2- There will be plasminogen
activators in the plasma
3- There will be plasminogen
activator inhibitors in plasma
4- There will be a tissue
plasminogen activator (tPA) which inhibits the platelets
Pathophysiology
29- A patient with pheochromocytoma is undergoing
surgery and has not been administered with alpha receptor blocker. If he is
administered with intravenous propranolol, then which of the following effects
will be evident?
1- There will be a rise in the
blood pressure
2- There will be a fall in the
blood pressure
3- The blood pressure will
remain unchanged
4- The patient may suffer
severe bronchoconstriction
Pharmacology of Autocoids
In conclusion, Pharmacology is a critical subject in the GPAT exam, and a good understanding of its key concepts and topics is essential to score high marks in the exam. Through our analysis of the previous year's Pharmacology paper, we have covered important topics and concepts, question types, and provided valuable tips on how to approach the questions effectively. We hope that this post has been helpful in your GPAT 2023 preparation and has provided you with the insights and guidance needed to perform well in the Pharmacology paper. Remember to stay updated with the latest exam pattern and syllabus, and practice as many mock tests as possible to improve your performance. With the right preparation and a positive attitude, you can crack the GPAT 2023 exam and achieve your dream of becoming a successful pharmacist. Good luck!
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